Central Pennsylvania’s Experts on Regenerative Orthopedics and Wellness

Call (717) 791-2860 today to get started on your way back to a healthier life.
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The Most Trusted Medical Practice In Central PA for Regenerative Orthopedics and Wellness.

Advanced PainCare and BioHealth Institute, a network affiliate of Regenexx®, specializes in the most advanced regenerative orthopedic care available. We are the trusted alternative to orthopedic surgery. Regenexx® procedures have helped thousands of patients improve their quality of life, return to the activities they enjoy, and avoid the need for surgery or joint replacement.

Our Wellness protocols are developed by studying the latest available research on hormone replacement, weight loss, and metabolic support. Because no two people have the same needs, each treatment is personalized to offer the greatest benefit.

Call (717) 791-2860 today to get started on your way back to a healthier life.

Services We Provide

We Accept Most Major Forms of Insurance


Advanced Pain Care and BioHealth Institute is in network with most major insurers. Click the link below to view our free market prices.

Meet the Experts

Both Dr. Santo and Jamie Shirey, CRNP, offer services unique to Central PA. .

Dr. Santo is a member of a very selective, highly-skilled, interventional orthopedics network that is 100% focused on orthopedic conditions. She is a musculoskeletal expert with extensive training and experience in the diagnosis and treatment of musculoskeletal conditions, as well as complex, image-guided injections of your body’s own healing agents to treat orthopedic issues.

Jamie Shirey is an Advanced Practitioner with a CRNP degree. She has extensive training and experience in evaluating and treating a variety of “Wellness” issues including obesity, low testosterone, women’s hormone balancing, thyroid dysfunction and inflammation. She is a thought leader for Wellness in Central PA.

Jean Louise Santo, MD

Medical Doctor

Conveniently Located In Central PA

Central PA's Leader In Non-Surgical Pain Relief and Wellness

We are passionate and comprehensive professionals that are here to listen to your needs and create a treatment plan to help you reach your personal health goals.